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Epigenetic Control of Gene Expression

Epigenetic Control of Gene Expression

30 hours
English
The University of Melbourne
Course by
CourseraCourses from Coursera
Certificate awarded
Intermediate

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Checklist

Certification

You will get a certificate on completing this course.

University

The course is from one of the top universities of the world - The University of Melbourne.

Difficulty

The students of this course have found this course easy.

Content

The students of this course have liked the content of this course.

Teaching

The students of this course have liked how the instructor has taught this course.

Satisfaction

The students of this course are overall satisfied with this course.

Why should you choose this course?

Description

While the human genome sequence has transformed our understanding of human biology, it isn't just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability. Importantly, unlike genetic mutations, epigenetic modifications are reversible and therefore have the potential to be manipulated therapeutically. It has also become clear in recent years that epigenetic modifications are sensitive to the environment (for example diet), which has sparked a large amount of public debate and research. This course will give an introduction to the fundamentals of epigenetic control. We will examine epigenetic phenomena that are manifestations of epigenetic control in several organisms, with a focus on mammals. We will examine the interplay between epigenetic control and the environment and finally the role of aberrant epigenetic control in disease. All necessary information will be covered in the lectures, and recommended and required readings will be provided. There are no additional required texts for this course. For those interested, additional information can be obtained in the following textbook. Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13: 978-0879697242 Edition: 1

Syllabus

Week 1 - Introduction to Epigenetic Control
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
Week 3 - Dosage Compensation
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
Week 5 - The Influence of the Environment on Epigenetic Control
Week 6 - Mechanisms of Environmental Influence on Epigenetic Control and Transgenerational Epigenetic Inheritance Through the Gametes
Week 7 - Cancer Epigenetics

What others say about this course

Reviews from Coursera

Definitelyan enchanting learning experience. This course expresses thoughts onepigenetics and how it could be the key to solve menacing threats such ascancer. It starts with a brief history and remarka  Read More ...

A great learning platform. This was my first ever course on coursera and I've thoroughly enjoyed it. A big thank you to Dr. Marnie Blewitt for helping us learn in a fun way!

It is a wonderful course to learn about epigenetics. I recommend everyone to take this course.

Truly a great course. Dr. Marnie Blewitt has been an amazing instructor.

Fantastic course excelente teacher thanks.

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